Can you take NAC and St. John's Wort together?
NAC modulates glutamate while SJW affects serotonin and other monoamines. The combined neurochemical effects are not well characterised.
Severity
Caution
Evidence
limited
Timing
Monitor mood if combining.
How it works
NAC modulates glutamate via the cystine-glutamate antiporter; SJW inhibits reuptake of serotonin, norepinephrine, and dopamine.
NAC has emerging evidence for mood support through glutamate modulation. The interaction of this glutamatergic effect with SJW's monoamine reuptake inhibition is poorly characterised in published research.
What to do
If combining, monitor mood and mental state closely. Start with low doses. The lack of interaction data warrants caution rather than avoidance.
Frequently asked
Should I separate NAC and St. John's Wort?
Consider separating them. Monitor mood if combining. Consult a healthcare professional for personalised advice.
Why do NAC and St. John's Wort interact?
NAC modulates glutamate via the cystine-glutamate antiporter; SJW inhibits reuptake of serotonin, norepinephrine, and dopamine.
How strong is the evidence for this interaction?
The evidence is limited. This interaction is based on theoretical mechanisms or a small number of studies.
About these supplements
Other NAC interactions
Other St. John's Wort interactions
Check your full stack
for interactions.
See what competes, what combines well, and when to take everything. Every interaction cites a published source.
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6 supplements
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1 flagZinc and Iron compete for the same absorption pathway. Take at least 2 hours apart.
Supplements
This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.