Can you take Rhodiola Rosea and St. John's Wort together?
Rhodiola mildly inhibits MAO enzymes while SJW inhibits monoamine reuptake. The combination may raise serotonin and dopamine more than either alone.
Severity
Caution
Evidence
limited
Timing
Low doses.
How it works
Rhodiola has mild MAO-A and MAO-B inhibitory activity; SJW inhibits monoamine reuptake. Both increase synaptic monoamine levels.
While the risk of serotonin syndrome is low at typical herbal doses, monitoring is prudent. The theoretical interaction parallels the well-known MAOI + SSRI contraindication, though at a much lower magnitude.
What to do
Use low doses and watch for agitation, restlessness, or mood changes. If side effects appear, discontinue one compound.
Frequently asked
Should I separate Rhodiola Rosea and St. John's Wort?
Consider separating them. Low doses. Monitor for agitation. Consult a healthcare professional for personalised advice.
Why do Rhodiola Rosea and St. John's Wort interact?
Rhodiola has mild MAO-A and MAO-B inhibitory activity; SJW inhibits monoamine reuptake. Both increase synaptic monoamine levels.
How strong is the evidence for this interaction?
The evidence is limited. This interaction is based on theoretical mechanisms or a small number of studies.
About these supplements
Other Rhodiola Rosea interactions
Other St. John's Wort interactions
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This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.