Can you take Coenzyme Q10 and St. John's Wort together?
St. John's Wort induces liver enzymes that may increase CoQ10 metabolism. Long-term SJW users may benefit from CoQ10 supplementation.
Severity
Caution
Evidence
limited
Timing
CoQ10 with a fatty meal.
How it works
SJW induces CYP3A4, which may accelerate the metabolic clearance of CoQ10 and other fat-soluble compounds.
The clinical significance is uncertain, but the enzyme induction is well-established. CoQ10 supplementation is a reasonable precaution for anyone on long-term SJW, similar to statin users adding CoQ10.
What to do
If you take St. John's Wort regularly, consider adding CoQ10. Take CoQ10 with a fat-containing meal. Timing relative to SJW does not matter.
Frequently asked
Should I separate Coenzyme Q10 and St. John's Wort?
Consider separating them. CoQ10 with a fatty meal. Timing relative to SJW flexible. Consult a healthcare professional for personalised advice.
Why do Coenzyme Q10 and St. John's Wort interact?
SJW induces CYP3A4, which may accelerate the metabolic clearance of CoQ10 and other fat-soluble compounds.
How strong is the evidence for this interaction?
The evidence is limited. This interaction is based on theoretical mechanisms or a small number of studies.
About these supplements
Other Coenzyme Q10 interactions
Other St. John's Wort interactions
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This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.