Can you take DHEA and St. John's Wort together?
St. John's Wort induces the liver enzymes that metabolise DHEA, potentially changing how it converts to testosterone and oestrogen.
Severity
Caution
Evidence
limited
Timing
Avoid combining without medical guidance.
How it works
SJW induces CYP3A4 and CYP2C19, key enzymes in steroid hormone metabolism that govern DHEA's downstream conversion.
DHEA converts to both testosterone and oestrogen. Altering its metabolic clearance with a CYP inducer can shift the balance unpredictably. Hormone-active supplements should generally be used cautiously alongside CYP inducers.
What to do
Avoid this combination without professional guidance. If you must take both, monitor hormone levels with blood work.
Frequently asked
Should I separate DHEA and St. John's Wort?
Consider separating them. Avoid combining without medical guidance. Consult a healthcare professional for personalised advice.
Why do DHEA and St. John's Wort interact?
SJW induces CYP3A4 and CYP2C19, key enzymes in steroid hormone metabolism that govern DHEA's downstream conversion.
How strong is the evidence for this interaction?
The evidence is limited. This interaction is based on theoretical mechanisms or a small number of studies.
About these supplements
Other DHEA interactions
Other St. John's Wort interactions
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This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.