Can you take Green Tea Extract and Quercetin together?
Quercetin inhibits COMT, the enzyme that inactivates green tea's primary catechin (EGCG). The result is higher effective EGCG levels for longer.
Severity
Info
Evidence
moderate
Timing
Together with food.
How it works
Quercetin inhibits catechol-O-methyltransferase (COMT), reducing the methylation and inactivation of EGCG.
COMT is the primary enzyme that degrades EGCG. Slowing this process extends EGCG's half-life and may increase its peak plasma concentration. The combination is popular in longevity-focused supplement protocols.
What to do
Take together with food. If your goal is to maximise EGCG's effects, adding quercetin is a well-reasoned approach.
Frequently asked
Should I separate Green Tea Extract and Quercetin?
This is an informational interaction. Green Tea Extract and Quercetin are generally fine to take together. Quercetin slows EGCG breakdown
Why do Green Tea Extract and Quercetin interact?
Quercetin inhibits catechol-O-methyltransferase (COMT), reducing the methylation and inactivation of EGCG.
How strong is the evidence for this interaction?
The evidence is moderate. Some studies support this interaction, but more research may be needed.
About these supplements
Other Green Tea Extract interactions
Other Quercetin interactions
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This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.