Can you take Creatine and Magnesium together?
Magnesium and creatine don't negatively interact. Both support the ATP energy system through complementary mechanisms.
Severity
Info
Evidence
moderate
Timing
Together at any time.
How it works
Creatine regenerates ATP via the phosphocreatine shuttle while magnesium is a cofactor for ATP-dependent enzymatic reactions.
Magnesium creatine chelate (MagnaPower) is a patented form that combines both molecules. Whether the chelated form is superior to taking them separately is debated, but there is no absorption conflict.
What to do
Take together at any time. Both can be taken with or without food. No separation needed.
Frequently asked
Should I separate Creatine and Magnesium?
This is an informational interaction. Creatine and Magnesium are generally fine to take together. No conflict — magnesium creatine chelate is a supplement form
Why do Creatine and Magnesium interact?
Creatine regenerates ATP via the phosphocreatine shuttle while magnesium is a cofactor for ATP-dependent enzymatic reactions.
How strong is the evidence for this interaction?
The evidence is moderate. Some studies support this interaction, but more research may be needed.
About these supplements
Other Creatine interactions
Other Magnesium interactions
Related reading
Check your full stack
for interactions.
See what competes, what combines well, and when to take everything. Every interaction cites a published source.
Stack
6 supplements
Stack review
1 flagZinc and Iron compete for the same absorption pathway. Take at least 2 hours apart.
Supplements
This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.