Can you take Caffeine and Yohimbe together?
Both powerfully increase sympathetic nervous system activity. Together, they can cause dangerous spikes in heart rate and blood pressure.
Severity
Warning
Evidence
moderate
Timing
Avoid combining entirely.
How it works
Yohimbine blocks alpha-2 adrenergic receptors, increasing norepinephrine release; caffeine antagonises adenosine receptors and raises catecholamines. The cardiovascular stimulation is synergistic.
The combination can cause hypertension, tachycardia, anxiety, and panic attacks. Particularly dangerous for people with pre-existing cardiovascular conditions, anxiety disorders, or hypertension.
What to do
Avoid this combination. If you take yohimbe, eliminate other stimulant sources. The cardiovascular risk is not dose-dependent in a predictable way.
Frequently asked
Should I separate Caffeine and Yohimbe?
Consider separating them. Avoid combining entirely. Consult a healthcare professional for personalised advice.
Why do Caffeine and Yohimbe interact?
Yohimbine blocks alpha-2 adrenergic receptors, increasing norepinephrine release; caffeine antagonises adenosine receptors and raises catecholamines. The cardiovascular stimulation is synergistic.
How strong is the evidence for this interaction?
The evidence is moderate. Some studies support this interaction, but more research may be needed.
About these supplements
Other Caffeine interactions
Check your full stack
for interactions.
See what competes, what combines well, and when to take everything. Every interaction cites a published source.
Stack
6 supplements
Stack review
1 flagZinc and Iron compete for the same absorption pathway. Take at least 2 hours apart.
Supplements
This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.