Can you take Iron and Manganese together?
Both use DMT1 for absorption. High-dose iron supplements can reduce manganese uptake and vice versa.
Severity
Caution
Evidence
moderate
Timing
Separate by 2+ hours.
How it works
Iron and manganese compete for DMT1 (divalent metal transporter 1) in the intestinal lining.
The competition is well-established at the transporter level. High iron intake can measurably reduce manganese absorption. At standard supplement doses, separating by two hours is sufficient to avoid meaningful interference.
What to do
Take iron in the morning and manganese at a different meal. Iron on an empty stomach, manganese with food.
Frequently asked
Should I separate Iron and Manganese?
Consider separating them. Separate by 2+ hours. Consult a healthcare professional for personalised advice.
Why do Iron and Manganese interact?
Iron and manganese compete for DMT1 (divalent metal transporter 1) in the intestinal lining.
How strong is the evidence for this interaction?
The evidence is moderate. Some studies support this interaction, but more research may be needed.
About these supplements
Other Iron interactions
Other Manganese interactions
Related reading
Check your full stack
for interactions.
See what competes, what combines well, and when to take everything. Every interaction cites a published source.
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1 flagZinc and Iron compete for the same absorption pathway. Take at least 2 hours apart.
Supplements
This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.