Can you take Nattokinase and Vitamin E together?
High-dose Vitamin E has antiplatelet effects. Combined with nattokinase's clot-dissolving activity, bleeding risk increases — mainly above 800 IU Vitamin E.
Severity
Caution
Evidence
moderate
Timing
Together at standard Vitamin E doses.
How it works
Vitamin E inhibits platelet cyclooxygenase and vitamin K-dependent clotting factors at high doses; nattokinase degrades fibrin directly.
At standard Vitamin E doses (100–400 IU), the additional bleeding risk is low. The concern is primarily above 800 IU/day, where Vitamin E's antiplatelet effects become clinically significant.
What to do
Keep Vitamin E at standard doses (400 IU or less) if combining with nattokinase. At these levels, the additional risk is minimal.
Frequently asked
Should I separate Nattokinase and Vitamin E?
Consider separating them. Together at standard Vitamin E doses. Consult a healthcare professional for personalised advice.
Why do Nattokinase and Vitamin E interact?
Vitamin E inhibits platelet cyclooxygenase and vitamin K-dependent clotting factors at high doses; nattokinase degrades fibrin directly.
How strong is the evidence for this interaction?
The evidence is moderate. Some studies support this interaction, but more research may be needed.
About these supplements
Other Nattokinase interactions
Other Vitamin E interactions
Related reading
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This information is for educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional.